1. I created a virtual machine and add channel: <channel type='unix'> <source mode='bind' path='/var/lib/libvirt/qemu/r-22-VM.agent'/> <target type='virtio' name='r-22-VM.vport'/> <address type='virtio-serial' controller='0' bus='0' port='1'/> </channel> 2. Use scripts,run this scripts is no error output #!/usr/bin/python import socket s=socket.socket(socket.AF_UNIX,socket.SOCK_STREAM) s.connect("/var/lib/libvirt/qemu/r-22-VM.agent") s.send("test\n") s.close 3. But i not read date in vm device /dev/vport0p1 (vm is run) My version, libvirt: 1.2.13.1 qmeu: 2.3.0 system: centos 6.5 This test in libvirt 1.0.5.7 qemu 1.5.3 is success. Please help , thanks